SYNTHESIS AND PHARMACOLOGICAL PROFILE OF 2 NOVEL HETEROCYCLIC CHROMANOLS, CP-80,798 AND CP-85,958, AS POTENT LTD(4) RECEPTOR ANTAGONISTS

Authors
ANDREWS EG ANTOGNOLI GW BRESLOW R CARTA MP CARTY TJ CHAMBERS RJ CHENG JB COHAN VL COLLINS JL DAMON DB DELEHUNT J EGGLER JF ESKRA JD FREIERT KW HADA WA MARFAT A MASAMUNE H MELVIN LS MULARSKI CJ NACLERIO BA PAZOLES CJ PILLAR JS RAPPACH LA REICHE P RUSEK FW SHERMAN H SHIRLEY JT SWEENEY FJ TICKNER JE WATSON JW WRIGHT CF
Citation
Eg. Andrews et al., SYNTHESIS AND PHARMACOLOGICAL PROFILE OF 2 NOVEL HETEROCYCLIC CHROMANOLS, CP-80,798 AND CP-85,958, AS POTENT LTD(4) RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 5(13), 1995, pp. 1365-1370
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
13
Year of publication
1995
Pages
1365 - 1370
Database
ISI
SICI code
0960-894X(1995)5:13<1365:SAPPO2>2.0.ZU;2-V
Abstract
The development of two novel LTD(4) receptor antagonists as clinical c andidates for the treatment of asthma is described. The first generati on compound, CP-80,798, was found to be a balanced 5-lipoxygenase inhi bitor (5-LOI)/LTD(4) antagonist (LTD(4)-A), while the second generatio n compound, CP-85,958, is a selective LTD(4) antagonist.