THE DISCOVERY OF CP-96,021 AND CP-96,486, BALANCED, COMBINED, POTENT AND ORALLY-ACTIVE LEUKOTRIENE D-4 (LTD(4)) PLATELET ACTIVATING FACTOR (PAF) RECEPTOR ANTAGONISTS/

Authors
MARFAT A CHAMBERS R CHENG J COOPER K DAMON D DELEHUNT J EGGLER J MASAMUNE H MELVIN L WATSON J
Citation
A. Marfat et al., THE DISCOVERY OF CP-96,021 AND CP-96,486, BALANCED, COMBINED, POTENT AND ORALLY-ACTIVE LEUKOTRIENE D-4 (LTD(4)) PLATELET ACTIVATING FACTOR (PAF) RECEPTOR ANTAGONISTS/, Bioorganic & medicinal chemistry letters, 5(13), 1995, pp. 1377-1382
Citations number
66
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
13
Year of publication
1995
Pages
1377 - 1382
Database
ISI
SICI code
0960-894X(1995)5:13<1377:TDOCAC>2.0.ZU;2-3
Abstract
The combination of key structural pharmacophores found in known leukot riene D-4 (LTD(4)) receptor antagonists with those of potent platelet activating factor (PAF) receptor antagonist UK-74,505 has led to the s ynthesis of hybrid compounds CP-96,021 and CP-96,486. These compounds represent the first known balanced, combined and orally active LTD(4)/ PAF receptor antagonists.