NOVEL INDOLACTAM-BASED INHIBITORS OF MATRIX METALLOPROTEINASES

Authors
CASTELHANO AL BILLEDEAU R DEWDNEY N DONNELLY S HORNE S KURZ LJ LIAK TJ MARTIN R UPPINGTON R YUAN ZY KRANTZ A
Citation
Al. Castelhano et al., NOVEL INDOLACTAM-BASED INHIBITORS OF MATRIX METALLOPROTEINASES, Bioorganic & medicinal chemistry letters, 5(13), 1995, pp. 1415-1420
Citations number
35
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
13
Year of publication
1995
Pages
1415 - 1420
Database
ISI
SICI code
0960-894X(1995)5:13<1415:NIIOMM>2.0.ZU;2-F
Abstract
Potent collagenase inhibitors incorporating a novel indolactam macrocy cle, which are accessible by the intramolecular alkylation of N-t-Boc- L-Trp-NH(CH2)(6)OTs under phase transfer conditions, show enhanced act ivity compared to their acyclic analogs.