BENZOTHIAZOLYLTHIO CARBAPENEMS - POTENT ANTI-MRSA AGENTS

Authors
WADDELL ST RATCLIFFE RW SZUMILOSKI SP WILDONGER KJ WILKENING RR BLIZZARD TA HUBER J KOHLER J DORSO K ROSE ES SUNDELOF JG HAMMOND GG
Citation
St. Waddell et al., BENZOTHIAZOLYLTHIO CARBAPENEMS - POTENT ANTI-MRSA AGENTS, Bioorganic & medicinal chemistry letters, 5(13), 1995, pp. 1427-1432
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
13
Year of publication
1995
Pages
1427 - 1432
Database
ISI
SICI code
0960-894X(1995)5:13<1427:BC-PAA>2.0.ZU;2-U
Abstract
A series of sulfur-linked benzothiazolyl carbapenems has been prepared and evaluated against a battery of microorganisms. Many of the compou nds displayed good activity against methicillin-resistant Staphylococc us aureus (MRSA). Data is presented which delimits the pharmacophore a nd provides a preliminary SAR.