PREIMPLANTATION ADOPTION - ESTABLISHING PREGNANCY USING DONATED OOCYTES AND SPERMATOZOA

The experience of transferring embryos produced through in-vitro ferti lization (IVF) utilizing donated oocytes and spermatozoa is described, Recipients (n = 28; aged 38-59 years) received oral micronized oestra diol and i.m. progesterone and were synchronized to donors undergoing ovarian stimulation. Reasons for selecting therapy included advanced r eproductive age (>42 years; n = 21) or hypergonadotrophic hypogonadism (n = 7), combined with severe male factor infertility in 23 couples, Five women were single and without partners, Oocytes were fertilized b y cryopreserved spermatozoa designated for use by the recipient, Up to five embryos were transferred transcervically, Supernumerary embryos were cryopreserved, A total of 36 aspirations produced 15.6 +/- 7.3 oo cytes per retrieval, In 10/36 cycles (27.8%), embryos were available f or cryopreservation, Using fresh embryos, the overall pregnancy rate w as 38.9% (14/36), clinical pregnancy rate 33.3% (12/36), and ongoing/d elivered pregnancy rate 30.6% (11/34), Three ongoing pregnancies were later established by transferring cryopreserved embryos. Adjusting for these events, the per aspiration overall pregnancy rate per retrieval was 47.2%, clinical pregnancy rate 41.7%, and ongoing/delivered pregn ancy rate 38.9%, Implantation rates per individual embryo transferred were 16.6% following fresh embryo transfer, A viable pregnancy was ach ieved by 14 of 28 women (50% cumulative pregnancy rate), We conclude t hat using donor oocytes and donor spermatozoa is efficacious and allow s couples of whom both members suffer from severe gamete abnormalities and single functionally agonadal women an effective means of achievin g pregnancy.