EFFECTS OF POSTNATAL ALUMINUM EXPOSURE ON BIOLOGICAL PARAMETERS IN THE RAT PLASMA

Young rats were treated by gastric intubation with aluminum chloride ( 100 mg Al/kg/day) and aluminum lactate (100 and 200 mg Al/kg/day) from postnatal days 5 to 14. This treatment lead to a reduction in body we ight. The plasma concentrations of total proteins and albumin decrease d whereas the oil globulins increased in the treated rats. The aluminu m concentrations in plasma and hepatic homogenates increased particula rly at 200 mg Al lactate. The reduction in average body weight could b e attributed to various causes: a decreased food consumption, a transi ent undernutrition, a reduction of the protein synthesis in the liver. The increase of the plasma concentration of the oil globulins reveale d an inflammation process.