AGE-RELATED-CHANGES IN THE SUSCEPTIBILITY TO CLOFIBRIC ACID, A HYPOLIPIDEMIC AGENT, OF MALE-RAT LIVER

Authors
YAMOTO T OHASHI Y TERANISHI M TAKAOKA M MANABE S MATSUNUMA N MAKITA T
Citation
T. Yamoto et al., AGE-RELATED-CHANGES IN THE SUSCEPTIBILITY TO CLOFIBRIC ACID, A HYPOLIPIDEMIC AGENT, OF MALE-RAT LIVER, Toxicology letters, 78(2), 1995, pp. 141-145
Citations number
18
Categorie Soggetti
Toxicology
Journal title
Toxicology letters → ACNP
ISSN journal
03784274
Volume
78
Issue
2
Year of publication
1995
Pages
141 - 145
Database
ISI
SICI code
0378-4274(1995)78:2<141:AITSTC>2.0.ZU;2-H
Abstract
Age-related changes in the susceptibility to clofibric acid were inves tigated in male F344 rats of 8, 52, and 117 weeks old., Hepatomegaly, decrease of serum total cholesterol and triglyceride, increase of the total cytochrome P-450 contents, induction of the activities of micros omal omega-hydroxylation and peroxisomal beta-oxidation, proliferation of smooth endoplasmic reticulum and peroxisomes were detected in 8- a nd 52-week-old rats. In 117-week-old rats clofibric acid treatment res ulted in decrease of serum total cholesterol, elevation of the activit ies of microsomal and peroxisomal enzymes, and slight proliferation of peroxisomes. These results suggest that the susceptibility of the mal e F344 rat liver to clofibric acid decreases in 117-week-old rats, tho ugh the effect is still recognizable.