T. Yamoto et al., AGE-RELATED-CHANGES IN THE SUSCEPTIBILITY TO CLOFIBRIC ACID, A HYPOLIPIDEMIC AGENT, OF MALE-RAT LIVER, Toxicology letters, 78(2), 1995, pp. 141-145
Age-related changes in the susceptibility to clofibric acid were inves
tigated in male F344 rats of 8, 52, and 117 weeks old., Hepatomegaly,
decrease of serum total cholesterol and triglyceride, increase of the
total cytochrome P-450 contents, induction of the activities of micros
omal omega-hydroxylation and peroxisomal beta-oxidation, proliferation
of smooth endoplasmic reticulum and peroxisomes were detected in 8- a
nd 52-week-old rats. In 117-week-old rats clofibric acid treatment res
ulted in decrease of serum total cholesterol, elevation of the activit
ies of microsomal and peroxisomal enzymes, and slight proliferation of
peroxisomes. These results suggest that the susceptibility of the mal
e F344 rat liver to clofibric acid decreases in 117-week-old rats, tho
ugh the effect is still recognizable.