Objective. Our goals were to document hospital costs associated with p
renatal cocaine exposure in an understudied population - women using r
ural county public health units who had minimal access to drug rehabil
itation and whose cocaine of choice was crack with little other illici
t drug use - and to explore why increased costs occur in an effort to
identify cost-reduction strategies. Methods. We identified a sample of
cocaine-exposed infants who were computer-matched to a control group
with no history or evidence of cocaine exposure. Matching was performe
d one-to-one on the variables of maternal race, age, parity, time of e
ntry into prenatal care, and alcohol and nicotine use. There were 327
live births, for whom 311 were correctly classified as to their prenat
al cocaine use and had billing and medical records available for revie
w (156 exposed, 155 nonexposed). Results. Hospital charges were positi
vely correlated with length of stay. Cocaine-exposed infants had an ac
ross-the-board increase in utilization of hospital resources as well a
s higher hospital charges and longer lengths of stay. Cocaine-exposed
infants were significantly younger in gestational age and lower in bir
th weight. Significantly more cocaine-exposed infants were admitted to
the neonatal intensive care unit, had more social and family problems
delaying discharge, and received more septic work-ups. In addition, o
f those infants urine-screened for cocaine at delivery, 92% were scree
ned secondary to a maternal history of prenatal use. Conclusions. Cost
-reduction strategies should be aimed at measures that reduce length o
f stay by addressing problems identified prenatally as an outpatient b
efore delivery and by influencing objective decision-making regarding
the need for medical interventions with the infant after birth.