INCREASES IN SRC-RELATED PROTEIN-TYROSINE KINASES IN HUMAN LIVER-CIRRHOSIS AND HEPATOCELLULAR-CARCINOMA

Authors
MASAKI T TOKUDA M OHNISHI M ITANO T MATSUI H WATANABE S ARIMA K KOHNO K MAEBA T TAI Y IKEDA Y HATANAKA Y HATASE O NISHIOKA M
Citation
T. Masaki et al., INCREASES IN SRC-RELATED PROTEIN-TYROSINE KINASES IN HUMAN LIVER-CIRRHOSIS AND HEPATOCELLULAR-CARCINOMA, HEPATOLOGY RESEARCH, 4(1), 1995, pp. 54-60
Citations number
13
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
HEPATOLOGY RESEARCH → ACNP
ISSN journal
13866346
Volume
4
Issue
1
Year of publication
1995
Pages
54 - 60
Database
ISI
SICI code
1386-6346(1995)4:1<54:IISPKI>2.0.ZU;2-A
Abstract
We examined the involvement of are-related tyrosine kinases (RTK) in v arious human liver diseases, such as chronic hepatitis (CH), liver cir rhosis (LC) and hepatocellular carcinoma (HCC), by Western blot and im munohistochemical analysis using an anti-src-RTK polyclonal antibody ( alpha-416). Our results showed that src-RTK were rarely found in the l iver tissues from CH patients, while they were found at high amounts i n those from LC and HCC patients. In addition, src-RTK were expressed more strongly in HCC than in LC. These results indicate that src-RTK m ay play important roles in the occurrence and development of LC and HC C.