SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 1-CYCLOPROPYL-6,8-DIFLUORO-7-(2-SUBSTITUTED AZOL-5-YL)-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID

Authors
KIM WJ KIM BJ LEE TS NAM KS KIM KJ
Citation
Wj. Kim et al., SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 1-CYCLOPROPYL-6,8-DIFLUORO-7-(2-SUBSTITUTED AZOL-5-YL)-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID, Heterocycles, 41(7), 1995, pp. 1389-1397
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
41
Issue
7
Year of publication
1995
Pages
1389 - 1397
Database
ISI
SICI code
0385-5414(1995)41:7<1389:SAAAO1>2.0.ZU;2-O
Abstract
Quinolone derivatives (9 and 10) substituted with bicyclothiazole (7) and (8) at C-7 position were synthesized. Bicyclothiazole derivatives (7 and 8) were prepared through 9 steps by way of the 4-bromo-3-oxopyr rolidine (16) was a key intermediate and introduced into the title com pounds as new C-7 substituents. In vitro antibacterial activity of 9 a nd 10 was also reported.