Mc. Smitt et al., THE IMPORTANCE OF THE LUMPECTOMY SURGICAL MARGIN STATUS IN LONG-TERM RESULTS OF BREAST-CONSERVATION, Cancer, 76(2), 1995, pp. 259-267
Background. The impact of the surgical margin status an long term loca
l control rates for breast cancer in women treated with lumpectomy and
radiation therapy is unclear. Methods. The records of 289 women with
303 invasive breast cancers who were treated with lumpectomy and radia
tion therapy from 1972 to 1992 were reviewed. The surgical margin was
classified as positive (transecting the inked margin), close (less tha
n or equal to 2 mm from the margin), negative, or indeterminate, based
on the initial biopsy findings and reexcision specimens, as appropria
te. Various clinical and pathologic factors were analyzed as potential
prognostic factors for local recurrence in addition to the margin sta
tus, including T classification, N classification, age, histologic fea
tures, and use of adjuvant therapy, The mean follow-up was 6.25 years.
Results. The actuarial probability of freedom from local recurrence f
or the entire group of patients at 5 and 10 years was 94% and 87%, res
pectively. The actuarial probability of local control at 10 years was
98% for those patients with negative surgical margins versus 82% for a
ll others (P = 0.007). The local control rate at 10 years was 97% for
patients who underwent reexcision and 84% for those who did not. Reexc
ision appears to convey a local control benefit for those patients wit
h close, indeterminate, or positive initial margins, when negative fin
al margins are attained (P = 0.0001). Final margin status was the most
significant determinant of local recurrence rates in univariate analy
sis, By multivariate analysis, the final margin status and use of adju
vant chemotherapy were significant prognostic factors. Conclusions. Th
e attainment of negative surgical margins, initially or at the time of
reexcision, is the most significant predictor of local control after
breast-conserving treatment with lumpectomy and radiation therapy.