STRUCTURE ELUCIDATION OF 2 DIPHENYLHYDANTOIN DERIVATIVES VIA H-1 AND C-13 NMR-SPECTROSCOPY

Authors
CIECHANOWICZRUTKOWSKA M RAGONA L GRECO F ZETTA L PEGNA M
Citation
M. Ciechanowiczrutkowska et al., STRUCTURE ELUCIDATION OF 2 DIPHENYLHYDANTOIN DERIVATIVES VIA H-1 AND C-13 NMR-SPECTROSCOPY, Magnetic resonance in chemistry, 33(7), 1995, pp. 586-591
Citations number
7
Categorie Soggetti
Spectroscopy,Chemistry
Journal title
Magnetic resonance in chemistry → ACNP
ISSN journal
07491581
Volume
33
Issue
7
Year of publication
1995
Pages
586 - 591
Database
ISI
SICI code
0749-1581(1995)33:7<586:SEO2DD>2.0.ZU;2-I
Abstract
The solution conformations of enzyl-5,5-diphenyl-2,4-dioxo-3-imidazoli dineacetic acid (AC) and lorobenzyl)-5,5-diphenyl-2,4-dioxo-1-imidazol idine acetic acid (AD) were studied by proton and carbon NMR spectrosc opy. The two drugs have different pharmacological activities, AC havin g anticonvulsant and AD having antidepressant but no anticonvulsant pr operties. The relative orientations of the hydantoin ring substituents were investigated and are discussed in terms of amphipathic distribut ion of polar and apolar domains.