Z. Durackova et al., SUPEROXIDE-DISMUTASE MIMETIC ACTIVITY OF A CYCLIC TETRAMERIC SCHIFF-BASE N-COORDINATED CU(II) COMPLEX, BioMetals, 8(3), 1995, pp. 183-187
A pulse radiolytic study using the cyclic tetrameric Schiff base N-coo
rdinated copper complex Cu(TAAB)(2+) has been performed, The reaction
of the Cu(TAAB)(2+) complex with superoxide revealed pseudo first-orde
r characteristics with the rate constant of k(2) = (2.9 +/- 0.5) x 10(
8) mol(-1) s(-1) dm(3), The complex survived the presence of competing
serum albumin in physiological concentrations, The complex stability
constant K = 1.15 x 10(18) (log K = 18.06) is two orders of magnitude
higher than that of Cu(II)-serum albumin (log K = 16.2), Transient cha
nges of the stability during the oxidation/reduction process and in th
e presence of 600 mu mol l(-1) albumin did not affect significantly ei
ther the electronic absorption of the complex or its catalytic activit
y,