SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 4 VASOPRESSIN ANALOGS MODIFIED IN POSITION 3 WITH BETA-THIENYLALANINE

Authors
SLANINOVA J CZAJA M LAMMEK B
Citation
J. Slaninova et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 4 VASOPRESSIN ANALOGS MODIFIED IN POSITION 3 WITH BETA-THIENYLALANINE, Collection of Czechoslovak Chemical Communications, 60(4), 1995, pp. 681-686
Citations number
17
Categorie Soggetti
Chemistry
Journal title
Collection of Czechoslovak Chemical Communications → ACNP
ISSN journal
00100765
Volume
60
Issue
4
Year of publication
1995
Pages
681 - 686
Database
ISI
SICI code
0010-0765(1995)60:4<681:SABO4V>2.0.ZU;2-O
Abstract
Four new analogs of arginine-vasopressin substituted in position 3 wit h beta-thienylalanine were synthesized on chloromethylated resin using Boc strategy and DCC or DCC-HOBt to form peptide bonds. The activity of the agonists is not much different in comparison to the unsubstitut ed compounds. However, the potency of one of the antagonists is strong ly reduced.