THE AMINO AND DEAMINO ANALOGS OF 8-D-HOMOARGININE-VASOPRESSIN WITH P-SUBSTITUTED PHENYLALANINE IN POSITION-2 IN ACTIVATION OF FACTOR-VIII AND TISSUE-PLASMINOGEN ACTIVATOR IN PRIMATES

Authors
VILHARDT H BARTH T ZERTOVA M PROCHAZKA Z VELEK J
Citation
H. Vilhardt et al., THE AMINO AND DEAMINO ANALOGS OF 8-D-HOMOARGININE-VASOPRESSIN WITH P-SUBSTITUTED PHENYLALANINE IN POSITION-2 IN ACTIVATION OF FACTOR-VIII AND TISSUE-PLASMINOGEN ACTIVATOR IN PRIMATES, Collection of Czechoslovak Chemical Communications, 60(4), 1995, pp. 697-704
Citations number
27
Categorie Soggetti
Chemistry
Journal title
Collection of Czechoslovak Chemical Communications → ACNP
ISSN journal
00100765
Volume
60
Issue
4
Year of publication
1995
Pages
697 - 704
Database
ISI
SICI code
0010-0765(1995)60:4<697:TAADAO>2.0.ZU;2-Q
Abstract
The replacement of L-Tyr in dDAVP by L-Tyr(Me), L- or D-Phe(pMe), L- o r D-Phe(pEt) in combination with substitution of D-arginine by D-homoa rginine resulted in dissociation of Factor VIII and tPA activating pro perties or in abilities to decrease the levels of circulating Factor V III and tPA levels in blood of squirrel monkeys.