ACYCLIC NUCLEOSIDE AND NUCLEOTIDE ANALOGS DERIVED FROM 2-AZAADENINE

Authors
HOCKOVA D MASOJIDKOVA M BUDESINSKY M HOLY A
Citation
D. Hockova et al., ACYCLIC NUCLEOSIDE AND NUCLEOTIDE ANALOGS DERIVED FROM 2-AZAADENINE, Collection of Czechoslovak Chemical Communications, 60(2), 1995, pp. 224-236
Citations number
20
Categorie Soggetti
Chemistry
Journal title
Collection of Czechoslovak Chemical Communications → ACNP
ISSN journal
00100765
Volume
60
Issue
2
Year of publication
1995
Pages
224 - 236
Database
ISI
SICI code
0010-0765(1995)60:2<224:ANANAD>2.0.ZU;2-2
Abstract
Alkylation of cesium salt of 2-azaadenine with appropriate synthons af forded the following acyclic analogs of nucleosides and nucleotides: ( S)-9-(2,3-dihydroxypropyl)-2-azaadenine (VI), 3-(2-azaadenin-9-yl)-2-h ydroxypropanoic acid (VIII), 9-(2-phosphonomethoxyethyl)-2-azaadenine (Xb), (R)-9-(2-phosphonomethoxypropyl)-2-azaadenine (XIb) and -(3-hydr oxy-2-phosphonomethoxypropyl)-2-azaadenine (XVIb). In some cases the N -2 isomers were also isolated.