SYNTHESIS OF BASE-MODIFIED ABBREVIATED NAD ANALOGS

Authors
JURICOVA K SMRCKOVA S HOLY A
Citation
K. Juricova et al., SYNTHESIS OF BASE-MODIFIED ABBREVIATED NAD ANALOGS, Collection of Czechoslovak Chemical Communications, 60(2), 1995, pp. 237-250
Citations number
23
Categorie Soggetti
Chemistry
Journal title
Collection of Czechoslovak Chemical Communications → ACNP
ISSN journal
00100765
Volume
60
Issue
2
Year of publication
1995
Pages
237 - 250
Database
ISI
SICI code
0010-0765(1995)60:2<237:SOBANA>2.0.ZU;2-9
Abstract
The ''abbreviated'' model of NAD, denin-9-yl)-2-hydroxypropyl]-3-carba moylpyridinium chloride (VIIIa), and its 2,6-diaminopurine (VIIIb), 3- deazaadenine (VIIIc), guanine (VIIId) and cytosine (VIIIe) analogues w ere prepared by the Zincke reaction. The (R)-isomer of the adenine mod el VIIIa (compound IX) was prepared for chiroptical studies. As shown by NMR, UV and CD spectra, neither in dimethyl sulfoxide nor in water any intramolecular pi-pi interactions exist between the heteroaromatic systems.