DIPYRIDAMOLE ATTENUATES THE DEVELOPMENT OF IMINODIPROPIONITRILE-INDUCED DYSKINETIC ABNORMALITIES IN RATS

The present investigation was undertaken to study the effect of dipyri damole on experimental dyskinesia in rats. The movement disorders were produced by intraperitoneal administration of iminodipropionitrile (I DPN) in the dose of 100 mg/kg per day for 12 days. Dipyridamole was ad ministered orally, daily 30 min before IDPN in the doses of 0.5 g/kg, 1 g/kg, and 1.5 g/kg bodyweight in three different groups of rats. Twe nty-four hours after the last dose of IDPN, animals were observed for neurobehavioral changes including vertical and horizontal head weaving , circling, backwalking, grip strength, and righting reflex; Immediate ly after behavioral studies brain specimens were collected for analysi s of vitamin E, conjugated dienes, and lipid hydroperoxides as indices of oxygen-derived free radical (OFR) production. Our results showed t hat concurrent use of dipyridamole significantly protected rats agains t IDPN-induced neurobehavioral changes in a dose-dependent manner. Tre atment of rats with dipyridamole inhibited IDPN-induced decrease of vi tamin E and increase in conjugated dienes and lipid hydroperoxides in brain. These findings suggest the involvement of OFR in dipyridamole i nduced protection against the development of IDPN dyskinesia. Further studies are warranted to determine the role of dipyridamole as a proph ylactic agent against the drug induced dyskinetic abnormalities.