ENZYMATIC SELECTIVE TRANSFORMATIONS OF DIETHYL FUMARATE

Authors
QUIROS M ASTORGA C REBOLLEDO F GOTOR V
Citation
M. Quiros et al., ENZYMATIC SELECTIVE TRANSFORMATIONS OF DIETHYL FUMARATE, Tetrahedron, 51(28), 1995, pp. 7715-7720
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
51
Issue
28
Year of publication
1995
Pages
7715 - 7720
Database
ISI
SICI code
0040-4020(1995)51:28<7715:ESTODF>2.0.ZU;2-O
Abstract
Candida antarctica lipase selectively catalyses transformations of die thyl fumarate in organic solvents. A range of nitrogen nucleophiles, i ncluding ammonia, can be succesfully used in these enzymatic reactions , monoamides and monohydrazides being obtained in high to moderate yie lds. In contrast, diethyl maleate is nor an adequate substrate for thi s enzyme.