3'-DEOXY-3'-(VINYLSULPHONYL)THYMIDINE - A NEW REACTIVE ANALOG OF AZT - ITS SYNTHESIS AND REACTIVITIES TOWARDS VARIOUS NUCLEOPHILES

Authors
BERA S SAKTHIVEL K PATHAK T LANGLEY GJ
Citation
S. Bera et al., 3'-DEOXY-3'-(VINYLSULPHONYL)THYMIDINE - A NEW REACTIVE ANALOG OF AZT - ITS SYNTHESIS AND REACTIVITIES TOWARDS VARIOUS NUCLEOPHILES, Tetrahedron, 51(28), 1995, pp. 7857-7866
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
51
Issue
28
Year of publication
1995
Pages
7857 - 7866
Database
ISI
SICI code
0040-4020(1995)51:28<7857:3-ANRA>2.0.ZU;2-J
Abstract
A reactive triatomic analogue of AZT, 3'-deoxy-3'-(vinylsulphonyl)thym idine has been synthesised from easily accessible starting material. T he vinyl-sulphone nucleoside was reacted with a variety of nucleophile s to generate new classes of modified nucleosides where the functional soups were attached to the C-3' of a nucleoside through flexible ethy l sulphone spacer.