This is a retrospective analysis of the medical records of patients di
agnosed to have large common bile duct stones (greater than or equal t
o 15 mm). The study was designed to evaluate different modalities of l
arge bile duct stone treatment. The setting is King Khalid University
Hospital, Gastroenterology Unit. The medical records of patients (n=64
) diagnosed to have large common bile duct stones by endoscopic retrog
rade cholangiography over a period of nine years were included. Files
were reviewed and information obtained which included patients' age, s
ex, nationality, presenting symptoms, number and size of bile duct sto
nes, presence of ascending cholangitis, mode of treatment received, co
mplications and outcome. There were a total of 64 patients; 28 males a
nd 36 females, with a mean age of 61 +/- 16.6 years. Successful stone
extraction was achieved in 44 (69%) patients while surgical treatment
was required in 20 patients. Surgically managed patients had significa
ntly larger stones (P<0.003) and were more frequently jaundiced (P<0.0
14). There was 7.8% of the total number of patients who developed comp
lications that were managed conservatively with full recovery. It was
concluded that large stones are difficult to extract endoscopically an
d more frequently require additional treatment.