SILVER(I), PALLADIUM(II), PLATINUM(II) AND PLATINUM(IV) COMPLEXES WITH ISOOROTATE AND 2-THIOISOOROTATE LIGANDS - SYNTHESIS, IR AND NMR-SPECTRA, THERMAL-BEHAVIOR AND ANTIMICROBIAL ACTIVITY

From the reaction of isoorotic and 2-thioisoorotic acids with Ag-I, Pd -II, Pt-II and Pt-IV ions, twelve new complexes containing the uracil ligand in either mono- or dianionic forms have been isolated and studi ed by conductivity measurements, i.r. and n.m.r. spectroscopies, and b y thermal methods (t.g. and d.s.c.). From the data obtained, tentative molecular structures are suggested for each complex. The most common coordination mode of both acids involves formation of a six-membered c helate ring through the exocyclic O(4) atom and an oxygen of the carbo xylate group. The antimicrobial activity of these compounds against se veral bacteria and yeast has also been assayed. It is noticeable that PdCl(H2CU). py complex is active against Pseudomonas sp. and Micrococc us sp. at MIC values lower than 50 mu g cm(-3).