COPPER(II) COMPLEXES OF 6-METHYL-2-ACETYLPYRIDINE N(4)-SUBSTITUTED THIOSEMICARBAZONES

Copper(II) complexes of 6-methyl-2-acetylpyridine N(4)-substituted thi osemicarbazones, coordinated either as a neutral or a monoanionic liga nd, have been prepared and characterized. I.r., electronic and e.p.r. spectra of the complexes, as well as H-1- and C-13-n.m.r. spectra of t he thiosemicarbazones, have been recorded. Both the thiosemicarbazones and their copper(II) complexes show either modest or no growth inhibi tory activity against Aspergillus niger, but the N(4)-dialkyl- and 3-a zacycloderivatives, and particularly their copper(II) complexes, have considerable activity against Paecilomyces variotii.