Iy. Lee et al., PRODUCTION OF POLY(BETA-HYDROXYBUTYRATE-CO-BETA-HYDROXYVALERATE) FROMGLUCOSE AND VALERATE IN ALCALIGENES-EUTROPHUS, Biotechnology letters, 17(6), 1995, pp. 571-574
Production of poly(beta-hydroxybutyrate-co-beta-hydroxyvalerate) [poly
(HB-co-HV)] in Alcaligenes eutrophus NCIMB 11599 was investigated at v
arious concentrations of valerate. With valerate, higher specific prod
uction rate, yield, and HV content of the copolymer were obtained than
those with propionate. By feeding valet-ate in the copolymer accumula
tion stage, a product titre as high as 90.4 g/l with HV content of 20.
4% could be obtained in 50 hr of fed-batch operation.