LACK OF CORRELATION BETWEEN DIARRHEA AND WEIGHT-LOSS IN HIV-POSITIVE OUTPATIENTS IN HOUSTON, TEXAS

To determine the prevalence of diarrhea and weight loss among human im munodeficiency virus (HIV)-positive patients, we reviewed the records of all patients attending the Harris County HIV Clinic during a 4-mont h time period. Diarrhea was considered persistent if it had been prese nt for >14 days or on two or more consecutive clinic visits. Weight lo ss was defined as moderate (5-10% reduction in weight) or severe (>10% reduction) when the present weight was compared with the weight found at the initial clinic visit. Records were reviewed for 1,370 patients , of whom 12.2% complained of diarrhea (7.7% acute and 4.5% persistent ). Diarrhea was more common among patients with a history of male-to-m ale sexual contact than in patients with other HIV risk factors (p < 0 .003 for acute and p < 0.006 for persistent). The mean CD4 cell count was not significantly different in patients with or without persistent diarrhea (176 versus 212) or acute diarrhea (215 versus 212). Weight loss was reported in 25.2% of subjects (12.8% moderate and 12.4% sever e). It did not correlate with CD4 count. Persistent diarrhea also was not associated with weight loss. Acute and persistent diarrhea were co mmon among ambulatory HIV-positive patients, particularly in homosexua l men. We did not identify a correlation among diarrhea, weight loss, and CD4 count. Thus, factors other than chronic diarrhea and immunosup pression appear to be responsible for weight loss in HIV-infected pati ents.