A RECOMBINATION EVENT IN THE CLOSELY LINKED PLASMINOGEN AND APOLIPOPROTEIN(A) GENE LOCI

Genetic studies as well as in situ hybridisation data have strongly de monstrated that the genes coding for apoprotein(a) and plasminogen are linked and localised to chromosome 6 at band 6q26-27. We describe in this report the presence of a recombination event in a region of appro ximately 50 kb of DNA separating the two genes. The recombination was found in an Italian family, in which a mutation affecting both plasmin ogen plasma level and activity of plasminogen activity has been detect ed. Polymerase chain reaction and sequencing analysis showed the prese nce of a mutation different from those previouly reported in two Japan ese families.