CONSTITUTIONAL HETEROMORPHISM OF 9Q13-]Q21 IN A PATIENT WITH CHRONIC MYELOGENOUS LEUKEMIA

Cytogenetic studies were carried out in a 44-year-old white male becau se of newly diagnosed chronic myelogenous leukemia. His initial bone m arrow study revealed 46,XY,var(9)(q13 --> q21)/46,XY,var(9) (q13 --> q 21), t(9;22)(q34;q11) karyotypes and later he also acquired a 47,XY,8,var(9)(q13 --> q21), t(9;22)(q34;q11) clone. The var(9)(q13 --> q21) heteromorphism was observed in the normal 9 homolog, in 200 GTG-bande d bone marrow metaphases in seven cytogenetic studies (1988-90). This heteromorphism was observed in the normal cell line, in the two chroni c myelogenous leukemia-related clones, as well as in 100 mitogen-induc ed peripheral blood lymphocytes, indicating its constitutional nature. This seems to be the first report of var(9)(q13 --> q21) heteromorphi sm, involving GTG-positive euchromatic band, in a chronic myelogenous leukemia proband.