MICROSCOPIC SELF-ORGANIZATION OF ENZYMATIC-REACTIONS IN SMALL VOLUMES

Authors
MIKHAILOV A HESS B
Citation
A. Mikhailov et B. Hess, MICROSCOPIC SELF-ORGANIZATION OF ENZYMATIC-REACTIONS IN SMALL VOLUMES, Journal of physical chemistry, 100(49), 1996, pp. 19059-19065
Citations number
16
Categorie Soggetti
Chemistry Physical
Journal title
Journal of physical chemistry → ACNP
ISSN journal
00223654
Volume
100
Issue
49
Year of publication
1996
Pages
19059 - 19065
Database
ISI
SICI code
0022-3654(1996)100:49<19059:MSOEIS>2.0.ZU;2-N
Abstract
Using an enzymic reaction with allosteric product activation as exampl e, we show that allosterically regulated reactions in small volumes ma y develop strong microscopic correlations between individual molecular reaction events. Such correlations lead to coherent synchronous activ ity of the enzymic molecular population which is revealed in frequent periodic spiking of the reaction.