Twenty-eight patients with 30 symptomatic simple renal cysts were trea
ted by percutaneous aspiration of the cyst and injection of 95% ethano
l. All patients were available for follow-up during a mean period of 1
9 (range 14-40) months. In all patients, successful resolution of the
cyst with disappearance of the symptoms was observed within 1 month af
ter treatment. During the whole period of follow-up, no patient experi
enced recurrence of symptoms or required repeat therapy. Of all renal
cysts treated, resolution was complete in 25 (83%) and partial (recurr
ence of <50% of original cyst volume with no symptoms) in 5 (17%). The
degree of response to sclerotherapy (whether complete or partial) cor
related significantly with cyst size (P>0.0008). Major complications w
ere not encountered, while microscopic hematuria was seen in two patie
nts, and low-grade fever was observed in another two. Ethanol scleroth
erapy is simple, noninvasive, and highly cost-effective and should be
recommended for the treatment of symptomatic simple renal cysts.