EVOLUTION OF BLOOD-COAGULATION AND FIBRINOLYSIS PARAMETERS AFTER ABRUPT VERSUS GRADUAL WITHDRAWAL OF ACENOCOUMAROL IN PATIENTS WITH VENOUS THROMBOEMBOLISM - A DOUBLE-BLIND RANDOMIZED STUDY

Authors
TARDY B TARDYPONCET B LAPORTESIMITSIDIS S MISMETTI P DECOUSUS H GUYOTAT D BERTRAND JC
Citation
B. Tardy et al., EVOLUTION OF BLOOD-COAGULATION AND FIBRINOLYSIS PARAMETERS AFTER ABRUPT VERSUS GRADUAL WITHDRAWAL OF ACENOCOUMAROL IN PATIENTS WITH VENOUS THROMBOEMBOLISM - A DOUBLE-BLIND RANDOMIZED STUDY, British Journal of Haematology, 96(1), 1997, pp. 174-178
Citations number
14
Categorie Soggetti
Hematology
Journal title
British Journal of Haematology → ACNP
ISSN journal
00071048
Volume
96
Issue
1
Year of publication
1997
Pages
174 - 178
Database
ISI
SICI code
0007-1048(1997)96:1<174:EOBAFP>2.0.ZU;2-J
Abstract
A double-blind randomized trial was conducted to research a hypercoagu lable state rebound after abrupt versus gradual withdrawal of acenocou marol. 20 patients were included: 10 in the abrupt withdrawal group (A W) and 10 in the gradual withdrawal group (GW). Between days 1 and 15, F1 + 2 was higher in group AW (P < 0 . 002). A significant increase o f D-dimer with time was found (P < 0 . 001) without difference between the two groups. tPA and PAI-1 levels remained stable throughout witho ut difference between the two groups. No rebound phenomenon was observ ed. Four thrombotic recurrences were observed: group AW: 1, group GW: 3 (P = 0 . 29). There is neither clinical nor biological support for a gradual anticoagulation withdrawal.