PERIODONTAL REGENERATIVE POTENTIAL OF SPACE-PROVIDING EXPANDED POLYTETRAFLUOROETHYLENE MEMBRANES AND RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEINS

A CONCEPT OF SPACE PROVISION TO SUPPORT SKELETAL REPAIR has long been used in orthopedic and oral maxillofacial reconstructive therapy. More recently, this concept has been studied and adapted to periodontal re constructive therapy. Other studies have demonstrated that skeletal ti ssues represent a significant reservoir of growth factors, including b one morphogenetic proteins. Such factors have been shown to stimulate skeletal repair in preclinical models and in clinical defects. We here in review studies using the critical size supraalveolar periodontal de fect model in which clinically meaningful periodontal regeneration was achieved following reconstructive surgery, including space provision by reinforced expanded polytetrafluoroethylene membranes or including surgical implantation of recombinant human bone morphogenetic protein- 2. Potential mechanisms involved in observed regeneration are discusse d.