ION-EXCHANGE RESINS FOR SOLUTION-PHASE PARALLEL SYNTHESIS OF CHEMICALLIBRARIES

Described are various techniques that employ ion-exchange resins for t he solution-phase synthesis of chemical libraries. We have found these resins to be useful as reagents and/or scavengers in a variety of rea ctions. Nine basic ion-exchange resins were evaluated for the catalysi s and purification of an amide synthesized from an acid chloride. A nu mber of the resins examined provided products in >95% purity. Acidic i on-exchange resins were also useful as scavengers in the synthesis of ureas. A demonstration of the utility of these resins for the preparat ion of amide, ester and urea libraries is also described. (C) 1997, El sevier Science Ltd. All rights reserved.