AN EFFICIENT AND SELECTIVE SYNTHESIS OF NAKIENONE-A INVOLVING A NOVELPROTOCOL FOR ALPHA-ALKENYLATION OF KETONES VIA PALLADIUM-CATALYZED ALKENYL-ALKENYL COUPLING

Authors
POUR M NEGISHI E
Citation
M. Pour et E. Negishi, AN EFFICIENT AND SELECTIVE SYNTHESIS OF NAKIENONE-A INVOLVING A NOVELPROTOCOL FOR ALPHA-ALKENYLATION OF KETONES VIA PALLADIUM-CATALYZED ALKENYL-ALKENYL COUPLING, Tetrahedron letters, 38(4), 1997, pp. 525-528
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
4
Year of publication
1997
Pages
525 - 528
Database
ISI
SICI code
0040-4039(1997)38:4<525:AEASSO>2.0.ZU;2-N
Abstract
Nakienone A was synthesized for the first time from 3-methoxy-2-cyclop entenone, dienyl iodide 7, and LICH(2)OMOM in 8 steps in 26% overall y ield with full control of the alkene geometry using the Pd-catalyzed c ross coupling reaction of a cyclopentenylzinc derivative 6a with 7 as a key step. (C) 1997, Elsevier Science Ltd. All rights reserved.