LOCAL-ANESTHETIC [2-(DECYLOXY)PHENYL]-2-(1-PIPERIDINYL)ETHYL ESTER OFCARBAMIC ACID PERTURBS PHOSPHATIDYLCHOLINE BILAYER

Authors
GALLOVA J CIZMARIK J BALGAVY P
Citation
J. Gallova et al., LOCAL-ANESTHETIC [2-(DECYLOXY)PHENYL]-2-(1-PIPERIDINYL)ETHYL ESTER OFCARBAMIC ACID PERTURBS PHOSPHATIDYLCHOLINE BILAYER, General physiology and biophysics, 14(1), 1995, pp. 61-65
Citations number
18
Categorie Soggetti
Physiology,Biophysics
Journal title
General physiology and biophysics → ACNP
ISSN journal
02315882
Volume
14
Issue
1
Year of publication
1995
Pages
61 - 65
Database
ISI
SICI code
0231-5882(1995)14:1<61:L[EO>2.0.ZU;2-7
Abstract
Monohydrochloride of [2-(decyloxy)phenyl]-2-(1-piperidinyl)ethyl ester of carbamic acid (C1OA) has a biphasic effect on the fluidity of egg yolk phosphatidylcholine (EYPC) model membranes as detected by the met hyl ester of stearic acid spin probe, with the paramagnetic doxyl grou p bound to C-16. The fluidity increases up to a molar ratio of C10A:EY PC=0.5 with a subsequent decrease. This decrease in fluidity may be du e to interdigitation of hydrocarbon chains in the bilayer.