EFFICIENT SOLID-PHASE SYNTHESIS OF SULFATED TYROSINE-CONTAINING PEPTIDES USING 2-CHLOROTRITYL RESIN - FACILE SYNTHESIS OF GASTRIN CHOLECYSTOKININ PEPTIDES/

Authors
KITAGAWA K AIDA C FUJIWARA H YAGAMI T FUTAKI S
Citation
K. Kitagawa et al., EFFICIENT SOLID-PHASE SYNTHESIS OF SULFATED TYROSINE-CONTAINING PEPTIDES USING 2-CHLOROTRITYL RESIN - FACILE SYNTHESIS OF GASTRIN CHOLECYSTOKININ PEPTIDES/, Tetrahedron letters, 38(4), 1997, pp. 599-602
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
4
Year of publication
1997
Pages
599 - 602
Database
ISI
SICI code
0040-4039(1997)38:4<599:ESSOST>2.0.ZU;2-5
Abstract
An efficient Fmoc-based solid-phase method for the synthesis of sulfat ed tyrosine-containing peptides is described. This synthetic approach involves two key features: (1) use of the 2-chlorotrityl resin as a so lid support, and (2) a two-step cleavage/deprotection protocol. Variou s molecular forms of gastrin-II and cholecystokinin (CCK) were prepare d by this approach without difficulty. (C) 1997, Elsevier Science Ltd. All rights reserved.