LIPOPHILIC MODIFICATION OF OLIGONUCLEOTIDES

Authors
TOMKINS JM BARNES KJ BLACKER AJ WATKINS WJ ABELL C
Citation
Jm. Tomkins et al., LIPOPHILIC MODIFICATION OF OLIGONUCLEOTIDES, Tetrahedron letters, 38(4), 1997, pp. 691-694
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
4
Year of publication
1997
Pages
691 - 694
Database
ISI
SICI code
0040-4039(1997)38:4<691:LMOO>2.0.ZU;2-V
Abstract
Methods for attaching lipophilic side-chains to an amino modified urac il base in oligonucleotides via orthogonal amide and disulphide linkag es are described. The oligonucleotide conjugates are characterised in terms of their distinctive chromatographic and spectroscopic propertie s. (C) 1997, Elsevier Science Ltd.