THALASSEMIA ALLELES IN MEXICAN MESTIZOS

Citation
B. Ibarra et al., THALASSEMIA ALLELES IN MEXICAN MESTIZOS, Revista de Investigacion Clinica, 47(2), 1995, pp. 127-131
Citations number
NO
Categorie Soggetti
Medicine, General & Internal
ISSN journal
00348376
Volume
47
Issue
2
Year of publication
1995
Pages
127 - 131
Database
ISI
SICI code
0034-8376(1995)47:2<127:TAIMM>2.0.ZU;2-#
Abstract
We present an analysis of the thalassemic alleles observed in Mexican mestizos. In 18 unrelated patients with mild to severe hemolytic anemi a we saw 16 with beta-thal and two with alpha-thal and identified 25 c hromosomes with 14 different alleles (10 for beta-thal), predominating the Mediterranean type (seven beta-thal and two alpha-thal). The most common mutation was the nonsense Cd 39 observed in seven chromosomes (28%); the other mutants were three Asian alleles, one beta-thal India n (IVS-1 nt 5 G-->C), two Southeast Asian alpha-thal (-(SEA) and the - (FIL)), one Kurdish Jew (-28 A-->C) and one Mexican (Cd 11 -T). These findings suggest a marked molecular heterogeneity in the thalassemia g enes in Mexico.