The causes of ischaemic stroke in young adults are many and diverse. S
uch patients usually require more extensive investigations in order to
find an underlying cause than more elderly patients. It is important
that a comprehensive search is made since many of the underlying disor
ders are treatable. Principal causes are extracranial arterial dissect
ion, cardioembolism, premature atherosclerosis, haematological and imm
unological disorders and migraine. Drug abuse is becoming increasingly
important but the risk of stroke in pregnancy remains unclear. Isolat
ed angiitis of the central nervous system, heritable disorders of conn
ective tissue and other genetically determined disorders (mitochondria
l cytopathies, CADASIL) account for a small proportion of ischaemic st
rokes in the young. Management is probably best undertaken by a physic
ian with a specialist interest and, if full investigation fails to elu
cidate a definite cause, the risk of future stoke is low.