Alcohol abuse is one of the most serious problems in public health and
the Wernicke-Korsakoff syndrome is one of the gravest consequences of
alcoholism. The pathology is often undiagnosed in its less evident pr
esentations, therefore an accurate diagnostic approach is a critical s
tep in treatment planning. Treatment is based on restoration of thiami
ne, although this is insufficient to prevent the psychological decline
of a great number of patients. The cognitive impact of the pathology
is derived from the interaction of alcoholic neurotoxicity, thiamine d
eficiency and personal susceptibility. In this article, the Literature
concerning Wernicke-Korsakoff syndrome is reviewed.