TURNING DOWN THE HEAT - NEW ROUTES TO INHIBITION OF INFLAMMATORY SIGNALING BY PROSTAGLANDIN H-2 SYNTHASES

Authors
MUNROE DG LAU CY
Citation
Dg. Munroe et Cy. Lau, TURNING DOWN THE HEAT - NEW ROUTES TO INHIBITION OF INFLAMMATORY SIGNALING BY PROSTAGLANDIN H-2 SYNTHASES, Chemistry & biology, 2(6), 1995, pp. 343-350
Citations number
33
Categorie Soggetti
Biology
Journal title
Chemistry & biology → ACNP
ISSN journal
10745521
Volume
2
Issue
6
Year of publication
1995
Pages
343 - 350
Database
ISI
SICI code
1074-5521(1995)2:6<343:TDTH-N>2.0.ZU;2-O
Abstract
Many nonsteroidal anti-inflammatory drugs act by inhibiting the cycloo xygenase activity oi prostaglandin H-2 synthase (PGHS), a key enzyme i n the biosynthesis of prostaglandins. Gastric toxicity remains a serio us problem with the current drugs, however. Recent advances in the und erstanding of PGHS now suggest two possible approaches to producing dr ugs with fewer side effects.