The benefit of thrombolytic therapy for acute myocardial infarction ha
s been conclusively established by many trials. Direct angioplasty (wi
thout thrombolytic therapy) is often utilized urgently for patients wi
th acute infarction based on observational studies. Recently, three ra
ndomized trials compared outcomes of patients undergoing thrombolysis
versus direct angio-plasty. The results of these trials indicate that
either strategy, if applied early, can benefit patients with acute inf
arction. Specific advantages of angioplasty include slightly higher pa
tency and flow rates in the infarct-related artery. However, thromboly
sis is more readily available to large segments of the population. Eit
her therapy must be applied early to be effective.