STRIATAL DOPAMINE D-1 RECEPTORS IN NARCOLEPSY - A PET STUDY WITH [C-11]NNC-756

Authors
RINNE JO HUBLIN C PARTINEN M RUOTTINEN H NAGREN K LEHIKOINEN P RUOTSALAINEN U LAIHINEN A
Citation
Jo. Rinne et al., STRIATAL DOPAMINE D-1 RECEPTORS IN NARCOLEPSY - A PET STUDY WITH [C-11]NNC-756, Journal of sleep research, 5(4), 1996, pp. 262-264
Citations number
10
Categorie Soggetti
Neurosciences,Physiology
Journal title
Journal of sleep research → ACNP
ISSN journal
09621105
Volume
5
Issue
4
Year of publication
1996
Pages
262 - 264
Database
ISI
SICI code
0962-1105(1996)5:4<262:SDDRIN>2.0.ZU;2-S
Abstract
We investigated dopamine D-1 receptors in the putamen and caudate nucl eus with positron emission tomography in six patients with narcolepsy and five healthy controls using [C-11]NNC 756 as ligand. The caudate-t o-cerebellum and putamen-to-cerebellum ratios of [C-11]NNC 756 were wi thin normal limits in patients with narcolepsy. No evidence of increas ed D-1 receptor binding in narcolepsy was found.