When the deterministic aberrations are known in an optical system, tra
ditional de-blurring methods are effective. However, when the aberrati
ons are difficult to quantify, such as telescope aberrations or the ab
errations in the human eye, other methods are needed. One potential me
thod for de-blurring an image that is formed from a system with unknow
n aberrations is the bispectral imaging method. It is a promising way
to remove the effects of deterministic aberrations when random aberrat
ions are present or artificially introduced into the system. Through c
omputer simulations, we have found the optimal amount of random aberra
tions to have present in a system containing deterministic aberrations
. This amount optimizes the image quality of the reconstruction at hig
h light levels using 100 statistically independent aberrated images of
the object. Defocus and several third-order aberrations were consider
ed in the isoplanatic case. The performance of this method was charact
erized by reconstructing a point source and computing its Strehl ratio
. These results are currently being used to incorporate the bispectral
imaging method as part of a non-invasive technique to reconstruct hig
h-resolution images of the back of the eye in human subjects.