DIMETHOXYETHANE AS A SOLVENT FOR THE SYNTHESIS OF C-MONOSUBSTITUTED O-CARBORANE DERIVATIVES

Dimethoxyethane is a reliable solvent for the synthesis of monosubstit uted derivatives of o-carborane. The reaction of o-carborane with 1 eq uiv of BuLi and the appropriate electrophile in dimethoxyethane yields the desired monosubstituted derivative. The 1,2-Li-2-1,2-C2B10H10 com pound is most probably avoided due to the bulkiness of the first Li(di methoxyethane) substituent (see diagram), blocking attack by a second Li(dimethoxyethane) group. The method encounters problems if C,C' ther modynamically stable rings can be formed.