AN ASCENDING NONOBSTRUCTIVE MODEL FOR CHRONIC PYELONEPHRITIS IN BALB C MICE/

Citation
R. Gupta et al., AN ASCENDING NONOBSTRUCTIVE MODEL FOR CHRONIC PYELONEPHRITIS IN BALB C MICE/, Journal of Medical Microbiology, 43(1), 1995, pp. 33-36
Citations number
19
Categorie Soggetti
Microbiology
ISSN journal
00222615
Volume
43
Issue
1
Year of publication
1995
Pages
33 - 36
Database
ISI
SICI code
0022-2615(1995)43:1<33:AANMFC>2.0.ZU;2-Q
Abstract
Chronic pyelonephritis was successfully produced in female BALB/c mice with Escherichia coli after introduction of the bacterial inoculum by the ascending route. E. coli strain 31-B, a nalidixic acid-resistant derivative of strain TN675 expressing type-1 pill, and E. coli strain BH-5, a mutant of 31-B, not expressing type-1 pill, were used in the m odel. Both the strains were able to induce chronic renal inflammation in the experimental animals. Whereas the initial colonisation was grea ter with strain 31-B, its non-pilate mutant BH-5 caused a significantl y greater inflammatory response and also caused renal scarring observa ble 5 months after the infection.