SEIZURES IN KLINEFELTERS-SYNDROME - A CLINICAL AND EEG STUDY OF 5 PATIENTS

In this study, we report the cases of five unrelated patients with Kli nefelter's syndrome and seizures or EEG epileptiform abnomalities, the karyotype was 47,XXY in four, and 47,XXY/46,XX in one, They were aged 13-25 years and followed up both clinically and by means of EEG. Two of the patients had epilepsy, one had only one isolated generalized to nic-clonic seizure, one had febrile convulsions and one presented foca l epileptiform EEG abnormalities without seizures, In two of the patie nts, it was possible to classify the epilepsy (childhood epilepsy with occipital paroxysms and cryptogenic or symptomatic generalized epilep sy), Although the electroclinical patterns appeared to be rather heter ogeneous in our patients, it is possible to infer the relative good ev olution of seizures in Klinefelter's syndrome.