THROMBOSIS OF CEREBRAL VEINS DURAL SINUSES AFTER PARATYPHI

A 20 year old woman was admitted to our Department 15 days after the o nset of typhoid fever treated with chloramphenicol, The patient showed intracranial hypertension with generalized seizures, slight right hem iparesis and a left VI cranial nerve deficit with diplopia, Magnetic R esonance Imaging (MRI) showed occlusion of the superior longitudinal, right transverse, right sigmoid sinus combined with a single hemorrhag ic infarct in the left occipito-parietal area, Serum tests were positi ve for Salmonella Paratyphi A and B, The results of cerebrospinal flui d (CSF) examination were normal and blood cultures were negative, Clin ical data, laboratory and MRI examinations indicate that the neurologi cal signs are the result of aseptic cerebral sinus thrombosis; the phy siopathologic mechanisms of the case are discussed.