We evaulated the intra- and inter-observer variability of depth measur
ements of the optic disc in cadaver eyes using the Glaucoma-scope, Int
ra-observer variation of 10 separately captured images became signific
antly greater with increasing depth of the optic cup (p < 0.001), The
standard deviation of depth measurements were 9.06 mu over the neural
rim, 25.00 mu along the cup wall, and 40.94 mu at the bottom of the op
tic cup, However, intra-observer variation of a single captured image
did not increase with greater optic cup depth, Intra-observer variatio
n, but not inter-observer variation, generally was greater when measur
ing the superior than inferior optic disc (p < 0.05), This study sugge
sts that when capturing separate optic disc images with the Glaucoma-s
cope, increased variation in depth measurements can be expected with g
reater optic cup depth and in the superior portion of the optic disc.