GUANOSINE 3',5'-BISPYROPHOSPHATE (PPGPP) SYNTHESIS IN CELLS OF ESCHERICHIA-COLI STARVED FOR P-I

Authors
SPIRA B SILBERSTEIN N YAGIL E
Citation
B. Spira et al., GUANOSINE 3',5'-BISPYROPHOSPHATE (PPGPP) SYNTHESIS IN CELLS OF ESCHERICHIA-COLI STARVED FOR P-I, Journal of bacteriology, 177(14), 1995, pp. 4053-4058
Citations number
35
Categorie Soggetti
Microbiology
Journal title
Journal of bacteriology → ACNP
ISSN journal
00219193
Volume
177
Issue
14
Year of publication
1995
Pages
4053 - 4058
Database
ISI
SICI code
0021-9193(1995)177:14<4053:G3(SIC>2.0.ZU;2-9
Abstract
Cells of Escherichia coli which enter a phase of starvation for P-i in duce the synthesis of the nucleotide guanosine 3',5'-bispyrophosphate (ppGpp). This induction is relA independent but depends on the spoT ge ne product. A mutant unable to produce ppGpp is impaired in the expres sion of two genes which belong to the pho regulon, a defect which is d ependent on the product of spoT. We suggest that ppGpp is essential fo r the proper induction of the genes which belong to the pho regulon.