NEUTRALIZATION OF FELINE IMMUNODEFICIENCY VIRUS BY POLYCLONAL FELINE ANTIBODY - SIMULTANEOUS INVOLVEMENT OF HYPERVARIABLE REGION-4 AND REGION-5 OF THE SURFACE GLYCOPROTEIN

Authors
SIEBELINK KHJ HUISMAN W KARLAS JA RIMMELZWAAN GF BOSCH ML OSTERHAUS ADME
Citation
Khj. Siebelink et al., NEUTRALIZATION OF FELINE IMMUNODEFICIENCY VIRUS BY POLYCLONAL FELINE ANTIBODY - SIMULTANEOUS INVOLVEMENT OF HYPERVARIABLE REGION-4 AND REGION-5 OF THE SURFACE GLYCOPROTEIN, Journal of virology, 69(8), 1995, pp. 5124-5127
Citations number
28
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
69
Issue
8
Year of publication
1995
Pages
5124 - 5127
Database
ISI
SICI code
0022-538X(1995)69:8<5124:NOFIVB>2.0.ZU;2-N
Abstract
Sites involved in antibody-mediated neutralization of feline immunodef iciency virus were mapped by reciprocal exchange of envelope fragments or amino acids between molecular clones of feline immunodeficiency vi rus with different susceptibilities to neutralization by a polyclonal cat serum. Combinations of mutations within HV-4 or within HV-4 and HV -5 changed the susceptibility of the viruses to neutralizing antibody.